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KMID : 0043320110340091443
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Archives of Pharmacal Research
2011 Volume.34 No. 9 p.1443 ~ p.1450
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Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica
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Zheng Ming Shan
Li Gao
Li Ying
Seo Chang-Seob
Lee Yeun-Kyung
Jung Jun-Sub
Song Dong-Keun
Bae Hong-Beom
Kwak Sang-Hyun
Chang Hyun-Wook
Kim Jae-Ryong
Son Jong-Keun
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Abstract
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In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (?)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-d-glucopyranoside (5), butyl (+)-5′-methoxyisolariciresinol-9′-O-β-d-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-d-fructofuranoside (10), and procyanidin B3 (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/d-GalN ranged from 80%?100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.
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KEYWORD
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Ulmus davidiana var. japonica, TNF-α, IL-6, IL-10, ALT
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